[Characterization of hypotonia-hyporesponsiveness after pentavalent vaccine and neurodevelopmental screening in children under 6 years of age, 2013-2018, Uruguay]. / Caracterización de la hipotonía-hiporrespuesta post vacuna pentavalente y tamizaje del neurodesarrollo en niños bajo 6 años de edad, 2013-2018, Uruguay.

BACKGROUND: Hypotonic-hyporesponsive episodes (HHE) is one frequently reported neurologic adverse effect supposedly attributable to vaccination and immunization. Its long-term impact on neurodevelopment is not completely known. AIM: To characterize the post-pentavalent vaccine HHE events reported to the Uruguayan Ministry of Health (M of H) between 2014 and 2018. To perform neurodevelopment screening of those who were under 6 years of age at the time of evaluation. METHODS: Descriptive study of the reports made to the National Farmacosurveillance System of the M of H. Neurodevelopment screening was performed using the National Guidelines for Developmental Surveillance. RESULTS: 30 cases were studied. Most cases occurred after the first doses, were of short duration and during the first hours after vaccination, with spontaneous recovery. Median time between the event and this evaluation was 2 years and 2 months. Screening tests were normal in 15. Delay in the language area was detected in one case. CONCLUSIONS: HHE events had similar characteristics to those described in the literature, with no severe short-term complications. Despite the limitations of the present study, no delays nor deviations were found in the development of the children who were evaluated.

Modelos epidemiológicos en la pandemia por SARS-CoV-2: concepto, aplicaciones y alcance / Epidemiological models in the SARS-CoV-2 pandemic: concept, applications and scope / Modelos epidemiológicos na pandemia de SARS-CoV-2: conceito, aplicações e escopo

Resumen: La pandemia por SARS-CoV-2, un nuevo coronavirus surgido en 2019, ha determinado una emergencia sanitaria y social mundial. Cada país optó por tomar acciones teniendo en cuenta su experiencia, analizando el impacto en las áreas de la salud, en lo económico y social, y aprendiendo de las experiencias comunicadas por otros países. El desarrollo de modelos epidemiológicos para obtener curvas estimativas de la situación de la enfermedad en la población y poder proyectar su evolución, adquiere especial importancia en un contexto de extrema incertidumbre, complejidad y dinamismo.

Abstract: The SARS-CoV-2 pandemic, a new coronavirus that emerged in 2019, has led to a global health and social emergency. Each country chose to take actions taking into account their experience, analyzing the impact in the areas of health, economically and socially, and learning from the experiences reported by other countries. The development of epidemiological models to obtain estimating curves of the disease situation in the population and to project its evolution, acquires special importance in a context of extreme uncertainty, complexity and dynamism.

Resumo: A pandemia de SARS-CoV-2, um novo coronavírus que surgiu em 2019, levou a uma emergência social e de saúde global. Cada país optou por tomar ações levando em consideração sua experiência, analisando o impacto nas áreas da saúde, econômica e socialmente, e aprendendo com as experiências relatadas por outros países. O desenvolvimento de modelos epidemiológicos para obter curvas de estimativa da situação da doença na população e projetar sua evolução, adquire importância especial em um contexto de extrema incerteza, complexidade e dinamismo.